Ginger (Gingerol) as an Anti-Tumour Medicine

Autori

  • Deepa Singh Sarojini Naidu Government Girls P.G. College, Bhopal, India

Cuvinte cheie:

Ginger, Gingerols, Bioactive compounds, Anti-cancerous

Rezumat

Ginger is a spice that is renowned for its characteristic aromatic fragrance and pungent taste, with documented healing properties. The scientific community has probed into the biological validation of its extracts and isolated compounds including the gingerols, shogaols, zingiberene, and zingerone, through in-vitro and in-vivo studies.

        Accordingly, this review highlights the mechanisms and therapeutics of ginger and its bioactive compounds focused on a anti-tumor and anti-cancerous context and these evidence are based on the (i) cytotoxic effect against cancer cell lines, (ii) enzyme inhibitory action, (iii) combination therapy with chemotherapeutic and phenolic compounds, (iv) possible links to the microbiome and (v) the use of nano-formulations of ginger bioactive compounds as a more effective drug delivery strategy in cancer therapy.

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Referințe

Marieb E. N. Essentials of Human Anatomy and Physiology. 8th. New York, NY, USA: Benjamin Cummings; 2005.

Rubio L., Motilva M.J., Romero M.P. Recent advances in biologically active compounds in herbs and spices: A review of the most effective antioxidant and anti-inflammatory active principles. Crit. Rev. Food Sci. Nutr. 2013;53:943–953. doi: 10.1080/10408398.2011.574802.

Majdalawieh A.F., Fayyad M.W. Immunomodulatory and anti-inflammatory action of Nigella sativa and thymoquinone: A comprehensive review. Int. Immunopharmacol. 2015;28:295–304. doi: 10.1016/j.intimp.2015.06.023.

Nilius B., Appendino G. Spices: The savory and beneficial science of pungency. Rev. Physiol. Biochem. Pharmacol. 2013;164:1–76.

Prasad S., Kim J. H., Gupta S. C., Aggarwal B. B. Targeting death receptors for TRAIL by agents designed by mother nature. Trends in Pharmacological Sciences. 2014;35(10):520–536. doi: 10.1016/j.tips.2014.07.004.

Aggarwal B. B., van Kuiken M. E., Iyer L. H., Harikumar K. B., Sung B. Molecular targets of nutraceuticals derived from dietary spices: potential role in suppression of inflammation and tumorigenesis. Experimental Biology and Medicine. 2009;234(8):825–849. doi: 10.3181/0902-mr-78.

Han Y.A., Song C.W., Koh W.S., Yon G.H., Kim Y.S., Ryu S.Y., Kwon H.J., Lee K.H. Anti-inflammatory effects of the Zingiberofficinale Roscoe constituent 12-dehydrogingerdione in lipopolysaccharide-stimulated raw 264.7 cells. Phytother. Res. 2013;27:1200–1205. doi: 10.1002/ptr.4847

Stoner G.D. Ginger: Is it ready for prime time? Cancer Prev. Res. 2013;6:257–262. doi: 10.1158/1940-6207.CAPR-13-0055.

Kumar N.V., Murthy P.S., Manjunatha J.R., Bettadaiah B.K. Synthesis and quorum sensing inhibitory activity of key phenolic compounds of ginger and their derivatives. Food Chem. 2014;159:451–457. doi: 10.1016/j.foodchem.2014.03.039.

Wei C., Tsai Y., Korinek M., Hung P., El-Shazly M., Cheng Y., Wu Y., Hsieh T., Chang F. 6-Paradol and 6-shogaol, the pungent compounds of ginger, promote glucose utilization in adipocytes and myotubes, and 6-paradol reduces blood glucose in high-fat diet-fed mice. Int. J. Mol. Sci. 2017;18:168. doi: 10.3390/ijms18010168.

Prasad S., Tyagi A.K. Ginger and its constituents: role in prevention and treatment of gastrointestinal cancer. Gastroent. Res. Pract. 2015;2015:142979. doi: 10.1155/2015/142979.

Descărcări

Publicat

2024-03-28

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Articles

Cum cităm

Singh, D. (2024). Ginger (Gingerol) as an Anti-Tumour Medicine. International Journal of Innovative Scientific Research, 2(1), 3-5. https://ijisr.net/ijisr/article/view/22

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