Assessing the Antimicrobial Potential of Sea Cucumber Holothuria leucospilota from the Ratnagiri Coast
Keywords:
Antimicrobial activity, Bioactive marine compounds, Holothuria leucospilota, Natural antibacterial agents, Ratnagiri coastAbstract
This research explores the antibacterial and antifungal potential of extracts from Holothuria leucospilota collected from the Ratnagiri coast and examines the relationship between total phenolic content (TPC) and antimicrobial activity. The study utilized methanol-based extracts from the body wall, cuvierian tubes, and visceral mass, assessing their efficacy against bacterial strains and Candida albicans through the disc diffusion. Additionally, TPC in each tissue extract was quantified using the Folin-Ciocalteu assay to determine its correlation with antimicrobial properties. Results indicated a significant link between TPC and the strength of antimicrobial activity, with the cuvierian tube extracts showing the highest TPC levels and the strongest antibacterial and antifungal effects. These findings underscore the potential of H. leucospilota as a valuable source of natural antimicrobial agents, potentially contributing to the development of alternative therapeutic compounds for combating microbial infections. The observed strong correlation between phenolic content and antimicrobial efficacy suggests that the bioactive compounds within the cuvierian tubes could be further studied for their mechanisms of action and potential applications in pharmaceutical formulations. This study supports the broader investigation of marine resources for their bioactive properties, emphasizing the importance of sustainable exploration for new antimicrobial agents in response to rising antibiotic resistance.
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